Comorbidities and VTE


Many diseases increase the risk of VTE (Illustration: MostPhotos.com)

Venous thromboembolism is a multicausal disease, and many diseases and conditions may contribute to increase the VTE risk in an individual.

In this project, we investigate the VTE risk in various diseases and conditions, such as respiratory symptoms and chronic obstructive pulmonary disease, infections, kidney function, diabetes, thyroid function, surgery and hospitalization for medical conditions.

Principal Investigator: John-Bjarne Hansen

Project members: Sigrid Brækkan, Trond Børvik, Ellen Brodin, Gro Grimnes, Esben Bjøri, Gunhild Lerstad

External collaborators: Hasse Melbye (Department of Community Medicine, UiT), Johan Svartberg and Rolf Jorde (Department of Clinical Medicine, UiT)

Meknas et al. Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study. TH Open. 2023;7:e244-e50.

Borvik et al. Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromso study. Res Pract Thromb Haemost. 2020;4:255-62.

Borvik et al. Chronic Obstructive Pulmonary Disease and Risk of Mortality in Patients with Venous Thromboembolism-The Tromso Study. Thromb Haemost. 2020;120:477-83.

Bjori et al. Hospitalization as a trigger for venous thromboembolism - Results from a population-based case-crossover study. Thromb Res. 2019;176:115-9.

Grimnes et al. C-reactive protein and risk of venous thromboembolism: results from a population-based case-crossover study. Haematologica. 2018;103:1245-50.

Grimnes et al. Acute infection as a trigger for incident venous thromboembolism: Results from a population-based case-crossover study. Res Pract Thromb Haemost. 2018;2:85-92.

Lerstad et al. Associations between serum levels of calcium, parathyroid hormone and future risk of venous thromboembolism: the Tromso study. Eur J Endocrinol. 2017;176:625-34.

Borvik et al. COPD and risk of venous thromboembolism and mortality in a general population. Eur Respir J. 2016;47:473-81.

Grimnes et al. Neutrophil to lymphocyte ratio and future risk of venous thromboembolism and mortality: the Tromso Study. Haematologica. 2016;101:e401-e4.

Lerstad et al. Thyroid function, as assessed by TSH, and future risk of venous thromboembolism: the Tromso study. Eur J Endocrinol. 2015;173:83-90.

Lerstad et al. Hyperglycemia, assessed according to HbA1c , and future risk of venous thromboembolism: the Tromso study. J Thromb Haemost. 2014;12:313-9.

Mahmoodi et al. Association of mild to moderate chronic kidney disease with venous thromboembolism: pooled analysis of five prospective general population cohorts. Circulation. 2012;126:1964-71

Brodin et al. Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function--the Tromso study. Haematologica. 2012;97:1008-13.



Members:

John Bjarne Hansen (Principal investigator)