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Obesity-related VTE


Previous studies have shown that obesity is associated with risk of future VTE. In this project, we aim to further elaborate on the relationship between obesity and VTE. Our long-term goal is to improve risk stratification for VTE in obesity and to identify molecular targets for intervention to prevent obesity-related VTE. 
Obesity has a substantial impact on VTE risk in the population (Illustration: MostPhotos.com)
In this project, we explore the linearity of the relationship between body mass index (BMI) and VTE risk as well as the impact of weight gain on VTE risk. We investigate the role of obesity-related cardiometabolic risk factors on the VTE risk and explore the combined effect of obesity and other genetic and environmental factors (life-style factors, comorbidities, etc.) on VTE risk. Furthermore, we study the association between adipose-tissue specific proteins and VTE risk (using targeted and proteome-wide approaches) and investigate their influence on VTE risk (mediation analyses) in obesity.

Principal Investigator: John-Bjarne Hansen

External collaborators: Tom Wilsgaard and Inger Njølstad (Department of Community Medicine, UiT), Ellisiv B. Mathiesen (Department of Clinical Medicine, UiT)

 

Publications:

Frischmuth et al. The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromso Study. Thromb Haemost. 2023.

Sejrup et al. Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromso Study. J Thromb Haemost. 2022; 20: 2342-9. 10.1111/jth.15812.

Frischmuth et al. Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism. Thromb Haemost. 2022; 122: 267-76. 10.1055/a-1497-9777.

Frischmuth et al. Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism. J Thromb Haemost. 2022; 20:1618-1626.

Frischmuth et al. Plasma Levels of Leptin and Risk of Future Incident Venous Thromboembolism. Thromb Haemost. 2022; 122: 560-9.

Horvei et al. Weight Change and Risk of Venous Thromboembolism: The Tromso Study. PloS one. 2016; 11: e0168878.

Horvei et al. C-reactive protein, obesity, and the risk of arterial and venous thrombosis. J Thromb Haemost. 2016; 14: 1561-71.

Horvei et al. Obesity measures and risk of venous thromboembolism and myocardial infarction. Eur J Epidemiol. 2014; 29: 821-30.

Braekkan et al. Role of obesity in the etiology of deep vein thrombosis and pulmonary embolism: current epidemiological insights. Semin Thromb Hemost. 2013; 39: 533-40.

Borch et al. Joint effects of obesity and body height on the risk of venous thromboembolism: the Tromso Study. Arterioscler Thromb Vasc Biol. 2011; 31: 1439-44.

Borch et al. Anthropometric measures of obesity and risk of venous thromboembolism: the Tromso study. Arterioscler Thromb Vasc Biol. 2010; 30: 121-7.

Borch et al. Abdominal obesity is essential for the risk of venous thromboembolism in the metabolic syndrome: the Tromso study. J Thromb Haemost. 2009; 7: 739-45.



Members:

John Bjarne Hansen (Principal investigator)
Sigrid Kufaas Brækkan
Vania Maris Morelli
Thor Ueland
Kristian Dalsbø Hindberg


Financial/grant information:

Stiftelsen K.G. Jebsen

Helse Nord (North Norwegian Regional Health Authority)